Center Personnel
Project 1 - Metabolomic Characterization of Botanical Chemistry and Synergy |
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Assistant Professor Guido F. Pauli, Project Leader Pauli, Guido F.: Assistant Professor, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (1993) Heinrich Heine-University Düsseldorf; Pharm.D., 1988, Philipps University Marburg. Research interests: Within the realm of modern pharmacognosy, investigation
of traditional as well as novel natural products by means of chemical,
biological, pharmacological and metabolome analysis. Research tools
are computer-aided structure elucidation, multidimensional and quantitative
NMR, modern chromatographic methods including countercurrent
chromatography, in tandem with in vitro and in vivo
biology and pharmacology as well as microbiological methods. Relying
on this tool chest, research focuses are in phytopharmacy and phytochemistry,
herbal dietary supplements, reference materials, anti-TB drugs and mycobacterial
secondary metabolites.
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Professor Norman R. Farnsworth, Co-Investigator Farnsworth, Norman R.: Research Professor, Department of Medicinal Chemistry and Pharmacognosy, UIC Distinguished Professor, Director of the Pharmacognosy Graduate Program, and Director of the WHO Collaborating Centre for Traditional Medicine, Ph.D. (1959) University of Pittsburgh Research interests: 1. Botanical, chemical, biological and clinical studies
on dietary supplements for women's health. |
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Research Assistant Professor Shao-Nong Chen, Co-Investigator
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Professor Doel D. Soejarto, Contributor Soejarto, D. Doel: Professor and Director of the Pharmacognosy Field Station, Department of Medicinal Chemistry and Pharmacognosy, and the Department of Biology, Ph.D. (1969) Harvard University Research interests: Taxonomy and conservation of plants, with special focus in Southeast Asia, particularly, Vietnam and Laos, and study of plants used in indigenous therapy, as well as tropical rainforest explorations of new and potential medicinal plants (bioprospecting), as part of collaborative research projects at UIC. I also study the taxonomy of the family Actinidiaceae. Since 1998, I have been directing an international collaborative program to study the biodiversity of Vietnam and Laos, as part of the International Cooperative Biodiversity Groups (ICBG) Program (http://www.fic.nih.gov/programs/icbg.html and http://www.uic.edu/pharmacy/research/icbg/ICBG.htm) of the Fogarty International Center, NIH. Our ICBG program activities include floristics and conservation at Cuc Phuong National Park; studies of medicinal plants of Laos; biological evaluation of plants of Vietnam and Laos using anti-HIV, anticancer, anti-TB and anti-malarial bioassays toward the discovery of biologically active molecules as potential candidates for pharmaceutical development; and the promotion of economic development among communities in Vietnam and Laos, where our ICBG work is being undertaken. Aside from UIC as base institution, our ICBG consortium members include Purdue University, Vietnamese Academy of Science and Technology in Hanoi (Institute of Biotechnology, Institute of Chemistry, and Institute of Ecology and Biological Resources), Cuc Phuong National Park (Vietnam), Traditional Medicine Research Center in Vientiane (Laos), and Bristol-Myers Squibb Co. (industrial partner). |
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Maria Florencia Rodriguez Brasco, Postdoctoral Research Associate
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Ayano Imai, Graduate Student
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Feng Qiu, Graduate Student
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Project 2 - Botanical Modulation of Estrogen Carcinogenesis |
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Professor Judy L. Bolton, Project Leader Bolton, Judy L.: Professor and Head, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (1988) University of Toronto Research interests: Chemical toxicology. The toxic effects elicited by dietary constituents often involves oxidative metabolism to electrophilic intermediates. We utilize chemical and biological approaches to study the cytotoxic/genotoxic mechanism including synthesis, spectroscopy, chromatography and enzymology. Metabolites and metabolic intermediates are identified, and their effects on various biochemical parameters studied. |
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Research Assistant Professor Birgit Dietz, Co-Investigator Dietz, Birgit M.: Research Assistant Professor, Department of Medicinal Chemistry and Pharmacognosy; Ph.D. (2002) Heinrich Heine-University Düsseldorf; Pharm.D. (1997) Heinrich Heine-University Düsseldorf, Germany.
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Tanvi Muni, Postdoctoral Research Associate
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Ping Yao, Research Specialist
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Project 3 - Metabolism, Safety and Efficacy |
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Professor Richard B van Breemen, Project Leader van Breemen, Richard B.: Professor, Department of Medicinal Chemistry and Pharmacognosy, Co-Director of the UIC/NIH Center for Dietary Supplements Research, and Assistant to the Director of the Research Resources Center, Ph.D. (1985) The Johns Hopkins University |
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Yong S. Choi, Postdoctoral Research Fellow "I obtained my PhD degree in Chemistry at the University of Illinois at Chicago and joined the UIC/NIH botanical center as a postdoctoral associate in 2006. The research I am pursuing in the botanical center is to screen natural products for ligands to estrogen receptors using mass spectrometry based assays. Especially pulsed ultrafiltration LC-MS, which was developed by our group in the botanical center, provides excellent selectivity, sensitivity, and structural information that facilitate the identification of ligands in complex mixtures such as botanical extracts." |
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Professor Lee Shulman, MD, Study Physician Lee Shulman: Clinical Interests are Hormonal Problems, Genetics - Reproductive, Genetics - Common Diseases, Genetics - Cancer, Amniocentesis, Chorionic Villi Sampling, Contraception Shulman works at Northwestern Memorial Hospital: (312) 926-6622 |
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Senior Research Specialist Suzanne Banuvar, Study Manager
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Soyoun Ahn, Graduate Student
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Kevin Krock, Graduate Student
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Andrew Newsome, Graduate Student
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Core A - Administration |
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Professor Norman R. Farnsworth, Center Director Farnsworth, Norman R.: Research Professor, Department of Medicinal Chemistry and Pharmacognosy, UIC Distinguished Professor, Director of the Pharmacognosy Graduate Program, and Director of the WHO Collaborating Centre for Traditional Medicine, Ph.D. (1959) University of Pittsburgh Research interests: 1. Botanical, chemical, biological and clinical
studies on dietary supplements for women's health. |
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Professor Richard B van Breemen, Center Co-Director van Breemen, Richard B.: Professor, Department of Medicinal Chemistry and Pharmacognosy, Co-Director of the UIC/NIH Center for Dietary Supplements Research, and Assistant to the Director of the Research Resources Center, Ph.D. (1985) The Johns Hopkins University |
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Associate Professor Marlos Viana, Biostatistics Component Marlos Viana, PhD is Associate Professor of Biostatistics in Ophthalmology. His current primary research is in the application of algebraic methods to the analysis and interpretation of data associated with symmetry conditions, with particular interest in statistical and linear optics, corneal topography, polarimetric data, statistical (molecular) chirality data, decompositions of entropy, and the study of short symbolic sequences. He has advised, taught, and collaborated with students at all graduate and undergraduate levels in a variety of theoretical and applied fields since 1978. He teaches at the Honors College and has a joint faculty appointment with the College of Pharmacy and the Honors College. He has served as faculty statistician at UIC's General Clinical Research Center and at UIC's Institutional Review Board. He is a member of several editorial boards and the editor of Vols 287 and 516 of the AMS's Contemporary Mathematics series. |
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Elizabeth C Krause, PharmD - Program Coordinator Liz earned her PharmD at the UIC College of Pharmacy preceded by a BS in biological sciences from the UIC College of Liberal Arts and Sciences. Previously, Liz was an assistant editor of a drug monograph series and separately, managed a medication use evaluation Program. Her interest in Complementary and Alternative Medicine (CAM) including botanical dietary supplements is long standing.She has also worked as a retail pharmacist in a CAM pharmacy providing prescription medications, botanical dietary supplements and homeopathic remedies, and is interested in preventative health care and health maintenance practices including exercise and meditation. |
Core B - Botanical Integrity Core |
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Assistant Professor Guido F. Pauli, Project Leader Pauli, Guido F.: Assistant Professor, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (1993) Heinrich Heine-University Düsseldorf; Pharm.D., 1988, Philipps University Marburg. Research interests: Within the realm of modern pharmacognosy, investigation
of traditional as well as novel natural products by means of chemical,
biological, pharmacological and metabolome analysis. Research tools
are computer-aided structure elucidation, multidimensional and quantitative
NMR, modern chromatographic methods including countercurrent
chromatography, in tandem with in vitro and in vivo biology and pharmacology as well as microbiological methods. Relying
on this tool chest, research focuses are in phytopharmacy and phytochemistry,
herbal dietary supplements, reference materials, anti-TB drugs and mycobacterial
secondary metabolites.
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Research Assistant Professor Shao-Nong Chen, Co-Investigator
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Professor Doel D. Soejarto, Contributor Soejarto, D. Doel: Professor and Director of the Pharmacognosy Field Station, Department of Medicinal Chemistry and Pharmacognosy, and the Department of Biology, Ph.D. (1969) Harvard University Research interests: Taxonomy and conservation of plants, with special focus in Southeast Asia, particularly, Vietnam and Laos, and study of plants used in indigenous therapy, as well as tropical rainforest explorations of new and potential medicinal plants (bioprospecting), as part of collaborative research projects at UIC. I also study the taxonomy of the family Actinidiaceae. Since 1998, I have been directing an international collaborative program to study the biodiversity of Vietnam and Laos, as part of the International Cooperative Biodiversity Groups (ICBG) Program (http://www.fic.nih.gov/programs/icbg.html and http://www.uic.edu/pharmacy/research/icbg/ICBG.htm) of the Fogarty International Center, NIH. Our ICBG program activities include floristics and conservation at Cuc Phuong National Park; studies of medicinal plants of Laos; biological evaluation of plants of Vietnam and Laos using anti-HIV, anticancer, anti-TB and anti-malarial bioassays toward the discovery of biologically active molecules as potential candidates for pharmaceutical development; and the promotion of economic development among communities in Vietnam and Laos, where our ICBG work is being undertaken. Aside from UIC as base institution, our ICBG consortium members include Purdue University, Vietnamese Academy of Science and Technology in Hanoi (Institute of Biotechnology, Institute of Chemistry, and Institute of Ecology and Biological Resources), Cuc Phuong National Park (Vietnam), Traditional Medicine Research Center in Vientiane (Laos), and Bristol-Myers Squibb Co. (industrial partner). |
Core C - Bioassay Core |
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Professor Judy L. Bolton, Project Leader Bolton, Judy L.: Professor and Head, Department of Medicinal Chemistry and Pharmacognosy, Ph.D. (1988) University of Toronto Research interests: Chemical toxicology. The toxic effects elicited by dietary constituents often involves oxidative metabolism to electrophilic intermediates. We utilize chemical and biological approaches to study the cytotoxic/genotoxic mechanism including synthesis, spectroscopy, chromatography and enzymology. Metabolites and metabolic intermediates are identified, and their effects on various biochemical parameters studied. |
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Research Assistant Professor Birgit Dietz, Co-Investigator Dietz, Birgit M.: Research Assistant Professor, Department of Medicinal Chemistry and Pharmacognosy; Ph.D. (2002) Heinrich Heine-University Düsseldorf; Pharm.D. (1997) Heinrich Heine-University Düsseldorf, Germany.
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Tewolde Tewolde, Graduate Student
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Ping Yao, Research Specialist
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Core D - Analytical |
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Professor Richard B van Breemen, Core Leader van Breemen, Richard B.: Professor, Department of Medicinal Chemistry and Pharmacognosy, Co-Director of the UIC/NIH Center for Dietary Supplements Research, and Assistant to the Director of the Research Resources Center, Ph.D. (1985) The Johns Hopkins University |
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Mass Spec Research Specialist Dejan Nikolic, Co-Investigator Dr. Nikolic is a Co-Investigator in the Analytical Core. He utilizes modern liquid chromatography-mass spectrometric approaches to determine the structure of active plant ingredients, their bioavailability, metabolic pathways and potential toxicity. He is also involved in quantitative determination of active ingredients in clinical specimens from patients enrolled in the clinical trials. |
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Research Associate Professor David C Lankin, Co-Investigator David C. Lankin Ph.D. (Organic Chemistry) - Research Associate Professor, Department of Medicinal Chemistry & Pharmacognosy UIC. He earned his Ph.D. at the University of Cincinnati (1972). Following a 2-year post-doctoral at the University of New Orelans (Gary W. Griffin / Photochemistry), he joined the Chemical Division of the Borg-Warner Corporation (Borg-Warner Chemicals). During the period (1974 - 1985) he was involved in developing and applying NMR technology at the Borg-Warner Research Center in Des Plaines, Illinois. In 1985, he moved to Varian Associates as an NMR Applications Chemist and was responsible for the operation of the Chicago NMR Applications Laboratory. In 1988 he joined the Physical Methodology Department of G.D. Searle (which later became Pharmacia Corporation in 2000 and Pfizer in 2002) where he was a Principal Research Scientist and Supervisor of the NMR Laboratory. He has co-authored > 60 papers in the field of organic chemistry with emphasis on the structural and quantitative applications of NMR. In 2000 he was awarded the Distinguished Service Award of the Chicago Section of The Society for Applied Spectroscopy. He is presently working (with Guido Pauli) in the UIC/NIH Botanical Center and is involved with the structure elucidation of natural products using NMR. |
