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Chun-Tao Che, Ph.D.Joanna Burdette

Norman R. Farnsworth Professor of Pharmacognosy
Department of Medicinal Chemistry and Pharmacognosy

University of Illinois at Chicago
College of Pharmacy
833 South Wood Street (M/C 781)
Chicago IL 60612-7231

Office: 323 PHARM
Office Phone: 312-996-5234
Lab: 551 PHARM
Fax Number: 312-996-7107
E-mail address: chect@uic.edu
Website: https://sites.google.com/site/whoictm/participants/che

Education:

The Chinese University of Hong Kong, B.Sc. (Biology), 1975
The Chinese University of Hong Kong, M.Phil. (Biochemistry), 1977
The University of Illinois at Chicago, Ph.D. (Pharmacognosy), 1982

Previous Positions Held:

Postdoctoral Chemist, Ludwig Institute for Cancer Research, Toronto, Canada (1982-1984)
Research Associate/Research Assistant Professor, Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago (1984-1991)
Associate Professor, Department of Chemistry, Hong Kong University of Science and Technology (1991-1998)
Professor and Director, School of Chinese Medicine, The Chinese University of Hong Kong (1998-2010)

Research Interests:

Interested in natural drugs and Chinese medicine, including:

  1. Natural products chemistry: isolation, characterization, and structural elucidation of secondary metabolites from medicinal plants and other natural sources
  2. Biologically active natural substances
  3. Chemical/biological standardization and quality assessment of herbal drugs and herb-based preparations
  4. Development of analytical techniques for herbal drug analysis
  5. Development of evidence-based Chinese medicine and other natural products

Publications (since 2010):

  1. .W.K. Cheung, C.M. Li, C.T. Che, B.P.L. Liu, L.J. Wang and W.K. Liu, Geoditin A induces oxidative stress and apoptosis on human colon HT29 cells. Mar. Drugs 8: 80-90, 2010.
  2. Y. He, M. Zhao, Y.Y. Zong, S.H. Tsai and C.T. Che, Chemical studies of Eurycorymbus cavaleriei. Zhongcaoyao (Chinese Herbal Durgs) 41: 36-39, 2010.
  3. Q.Q. Mao, Y.F. Xian, S.P, Ip, S.H. Tsai and C.T. Che, Long-term treatment with peony glycosides reverses chronic unpredictable mild stress-induced depressive-like behavior via increasing expression of neurotrophins in rat brain. Behavioural Brain Res. 210: 171-177, 2010.
  4. S.P. Ip, M. Zhao, Y.F. Xian, M.L. Chen, Y.Y. Zong, Y.W. Tjong, S.H. Tsai, J.J.Y. Sung, A. Bensoussan, B. Berman, H.H.S. Fong and C.T. Che, Quality assurance program for Chinese herbal formulae: Standardization of a 20-herb preparation for the treatment of irritable bowel syndrome. Chin. Med. (BioMed Central, UK), 2010. http://www.cmjournal.org/content/pdf/1749-8546-5-8.pdf. PMCID: PMC2845568.
  5. W.K.K. Wu, C.H. Cho, C.W. Lee, Y.C. Wu, L. Yu, Z.J. Li, C.C.M. Wong, H.T. Li, L. Zhang, S.X. Ren, C.T. Che, K. Wu, D. Fan, J. Yu and J.J. Sung, Macroautophagy and ERK phosphorylation counteract the antiproliferative effect of proteasome inhibitor in gastric cancer cells. Autophagy 6: 228-238, 2010.
  6. M.L. Chen, S.P. Ip, S.H. Tsai, K.M. Ko and C.T. Che, Biochemical mechanism of Wu-Zi-Yan-Zong-Wan, a traditional Chinese herbal formula, against alcohol-induced oxidative damage in CYP2E1 cDNA-transfected HepG2 (E47) cells. J. Ethnopharmacol. 128: 116-122, 2010.
  7. Q.Q. Mao, Z. Huang, X.M. Zhong, C.R. Feng, A.J. Pan, Z.Y. Li, S.P. Ip and C.T. Che, Effects of SYJN, a Chinese herbal formula, on chronic unpredictable stress-induced changes in behavior and brain BDNF in rats. J. Ethnopharmacol. 128: 336-341, 2010. 
  8. Y.W. Tjong, S.P. Ip, L. Lao, J. Wu, H.H.S. Fong, J.J.Y. Sung, B. Berman and C.T. Che, Neonatal maternal separation elevates thalamic corticotrophin releasing factor type 1 receptor expression response to colonic distension in rat. Neuroendocrinol. Lett.31: 215-220, 2010.
  9. H. Li, W.K. Wu, Z. Zheng, C.T. Che, Z.J. Li, D.D. Xu, C.C. Wong, C.G. Ye, J.J.Y. Sung, C.H. Cho and M. Wang, 3,3',4,5,5'-pentahydroxy-trans-stilbene, a resveratrol derivative, induces apoptosis in colorectal carcinoma cells via oxidative stress. Eur. J. Pharmacol. 637: 55-61, 2010.
  10. J. Cao, M.L. Chen, P. Ip and C.T. Che, Correlative study on the quality of Herba Desmodii Styracifolii. Chin. Trad. Herbal Drugs (Zhongcaiyao) 41: 643-647, 2010. (In Chinese)
  11. Z.X. Lin, B.W. Jiao, C.T. Che, Z. Zuo, C.F. Mok, M. Zhao, W.K.K. Ho, W.P. Tse, K.Y. Lam, R.Q. Fan, Z.J. Yang and C.H.K. Cheng, Ethyl acetate fraction of the root of Rubia cordifolia L. inhibits keratinocyte proliferation in vitro and promotes keratinocyte differentiation in vivo: potential application for psoriasis treatment. Phytother. Res. 24: 1056-64, 2010.
  12. M.L. Chen, Y.F. Xian, S.P. Ip, S.H. Tsai, J.Y. Yang and C.T. Che, Chemical and biological differentiation of Cortex Phellodendri Chinensis and Cortex Phellodendri Amurensis. Planta Med. 76: 1530-1535, 2010.
  13. M. Zhao, Y.F. Xian, S.P. Ip, H.H.S. Fong, C.T. Che, A new and weakly antispasmodic protoberberine alkaloid from Rhizoma Coptidis. Phytother. Res. 24: 1414-1416, 2010.
  14. M.L. Chen, S.H. Tsai, S.P. Ip, K.M. Ko and C.T. Che, Long-term treatment with a “Yang- invigorating” Chinese herbal formula, Wu-Zi-Yan-Zong-Wan, reduces mortality and liver oxidative damage in chronic alcohol intoxicated rats. Rejuvenation Res. 13: 459-467, 2010.
  15. F.W.K. Cheung, C.T. Che, H. Sakagami, M. Kochi and W.K. Liu, Sodium 5,6-benzylidene-L-ascorbate induces oxidative stress, autophagy and growth arrest in human colon cancer HT-29 cells. J. Cell. Biochem. 111: 412-424, 2010.
  16. X.L. Dong, Y. Zhang, M.J. Favus, C.T. Che and M.S. Wong, Ethanol extract of Fructus Ligustri Lucidi increases circulating 1,25-dihydroxyvitamin D3 by inducing renal 25-hydroxyvitamin D-1alpha hydroxylase activity. Menopause 17: 1174-1181, 2010.
  17. Y. Chen, S.P. Ip, K.M. Ko, T.C.W. Poon, E.W.Y. Ng, P.B.S. Lai, Q.Q. Mao, Y.F. Xian, and C.T. Che, A proteomic approach in investigating the hepatoprotective mechanism of schisandrin B: Role of Raf kinase inhibitor protein. J. Proteome Res. 10: 299-304, 2011.
  18. Q.Q. Mao, Y.F. Xian, S.P. Ip, S.H. Tsai and C.T. Che, Protective effects of peony glycosides against corticosterone-induced cell death in PC12 cells through antioxidant action. J. Ethnopharmacol. 133: 1121-1125, 2011.
  19. S. Ouyang, L. Wang, Q.W. Zhang, G.C. Wang, Y. Wang, X.J. Huang, X.Q. Zhang,R.W. Jiang, X.S.Yao, C.T. Che and W.C. Ye, Six new monoterpenoid indole alkaloids from the aerial part of Gelsemium elegans. Tetrahedron 67: 4807-4813, 2011.
  20. Y. He, L. Zhang, M. Zhao, S.H. Tsai, Y.Y. Zong and C.T. Che, Phenolic compounds from Eurycorymbus cavaleriei. J. Asian Nat. Prod. Res. 13: 575-580, 2011.
  21. Q.Q. Mao, Y.F. Xian, S.P. Ip and C.T. Che, Involvement of serotonergic system in the antidepressant-like effect of piperine. Neuro-Psychopharmacol. Biol. Psychiatry 35: 1144-1147, 2011.
  22. R. Feng, J.G. Shi, X.W. Liu, C.T. Che, J.H.K. Yeung and Y. Wang, Identification of the metabolites of biologically active xanthones isolated from Halenia elliptica D. Don by high-performance liquid chromatography coupled to ion trap time-of-flight mass spectrometry. Chin. Chem. Lett. 22: 839-842, 2011.
  23. Y.W. Tjong, S.P. Ip, L. Lao, H.H.S. Fong, J.J.Y. Sung, B. Berman and C.T. Che, Analgesic effect of Coptis chinensis rhizomes (Coptidis Rhizoma) extract on rat model of irritable bowel syndrome. J. Ethnopharmacol. 135: 754-761, 2011.
  24. J.Y. Chan, J.C. Koon, P.C. Leung, C.T. Che and K.P. Fung, Suppression of low-density lipoprotein oxidation, vascular smooth muscle cell proliferation and migration by a herbal extract of Radix Astragali, Radix Codonopsis and Cortex Lycii. BMC Comp. Altern. Med. 11, 32, 2011.
  25. J.M. Yang, J.H.K. Yeung, P.S.P Ip and C.T. Che, HPLC-MS analysis of Schisandra lignans and their metabolites in Caco-2 cell monolayer and rat everted gut sac models and in rat plasma. Acta Pharm. Sinica (B), 1: 46-55, 2011.
  26. Y.W. Tjong, S.P. Ip, L. Lao, J. Wu, H.H.S. Fong, J.J.Y. Sung, B. Berman and C.T. Che, Role of neuronal nitric oxide synthase in colonic distension-induced hyperalgesia in distal colon of neonatal maternal separated male rats. Neurogastroenterol. Motility 23: 666-e278, 2011.
  27. J.M. Yang, P.S.P Ip, J.H.K. Yeung and C.T. Che, Inhibitory effect of schisandrin on spontaneous contraction of isolated rat colon. Phytomedicine 18: 998-1005, 2011.
  28. J.M. Yang, P.S.P. Ip, C.T. Che and J.H.K. Yeung, Relaxant effects of Schisandra chinensis and its major lignans on agonists-induced contraction in guinea pig ileum. Phytomedicine 18: 1153-1160, 2011.
  29. B.X. Zhao, Y. Wang, D.M. Zhang, R.W. Jiang, G.C. Wang, J.M. Shi, X.J. Huang, W.M. Chen, C.T. Che and W.C. Ye, Flueggines A and B, Two novel dimeric indolizidine alkaloids from Flueggea virosa. Org. Lett. 13: 3888-3891, 2011.
  30. L.L. Zhou, Z.X. Lin, K.P. Fung, C.H.K. Cheng, C.T. Che, M. Zhao, S.H. Wu and Z. Zuo, Celastrol-induced apoptosis in human HaCaT keratinocytes involves the inhibition of NF-κB activity. Eur. J. Pharmacol., 670: 399-408, 2011.
  31. Y.F. Xian, Q.Q. Mao, S.P. Ip, Z.X. Lin and C.T. Che, Comparison on the anti-inflammaotry effect of Cortex Phellodendri Chinensis and Cortex Phellodendri Amurensis in 12-O-tetradecanoyl-phorbol-13-acetate-induced ear edema in mice. J. Ethnopharmacol. 137: 1425-1430, 2011.
  32. Q.Q. Mao, Z. Huang, S.P. Ip, Y.F. Xian and C.T. Che, Role of 5-HT1A and 5-HT1B receptors in the antidepressant-like effect of piperine in the forced swim test. Neurosce. Lett. 504: 181-184, 2011.
  33. M. Zhao, S.T. Lau, X.Q. Zhang, W.C. Ye, P.S. Leung, C.T. Che and Z.X. Lin, Bruceines K and L from the Ripe Fruits of Brucea javanica. Helv. Chim. Acta 94: 2099-2105, 2011.
  34. M. Zhao, S.T. Lau, P.S. Leung, C.T. Che and Z.X. Lin, Seven quassinoids from Fructus Bruceae with cytotoxic effects on pancreatic adenocarcinoma cell lines. Phytother. Res. 25: 1796-1800, 2011.
  35. Y.F. Xian, Z.X. Lin, M. Zhao, Q.Q. Mao, S.P. Ip and C.T. Che, Uncaria rhynchophylla ameliorates cognitive deficits induced by D-galactose in mice. Planta Med. 77: 1977-1983, 2011.
  36. Q.Q. Mao, Z. Huang, S.P. Ip, Y.F. Xian and C.T. Che, Peony glycosides reverse the effects of corticosterone on behavior and brain BDNF expression in rats.Behavioural Brain Res. 227: 305-309, 2012.
  37. Q.Q. Mao, S.P. Ip, Y.F. Xian, Z. Hu and C.T. Che, Antidepressant-like effect of peony: A mini-review. Pharm. Biol. 50:72-77, 2012.
    J.M. Yang, P.S.P. Ip, J.C.Y. Wu, L. Lao, H.H.S. Fong, J.J.Y. Sung, B. Berman, J.H.K. Yeung and C.T. Che, Schisandra chinensis reverses visceral hypersensitivity in a neonatal-maternal separated rat model. Phytomedicine, in press, 2012.
  38. X.L. Dong, M. Zhao, K.K. Wong, C.T. Che and M.S. Wong, Improvement of Ca balance by Fructus Ligustri Lucidi extract in mature female rats was associated with the induction of serum parathyroid hormone levels. Brit. J. Nutri., 2012, in press.
  39. H.W. Zhang, Y.F. Ho, C.T. Che, Z.X. Lin, C. Leung and L.S. Chan, Topical herbal application as an adjuvant treatment for chronic kidney disease - a systematic review of randomized controlled clinical trials. J. Adv. Nursing, 2012, in press.
  40. J.M. Yang, S.P. Ip, Y.F. Xian, M. Zhao, Z.X. Lin, J.H.K. Yeung, R.C.Y. Chan, S.S. Lee and C.T. Che, Impact of the herbal medicine Sophora flavescens on the oral pharmacokinetics of indinavir in rats: The involvement of CYP3A and P-glycoprotein. PLoS One, 2012, accepted for on-line publication.

 

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