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Harry H.S. Fong, Ph.D. Harry Fong

Professor Emeritus of Pharmacognosy
Department of Medicinal Chemistry and Pharmacognosy

University of Illinois at Chicago
College of Pharmacy
833 S. Wood Street (M/C 781)
Chicago, IL 60612-7231

Office: 118B2 PHARM
Office Phone: 630-854-9303 (mobile)
Fax Number: 312-996-7107
E-mail address: hfong@uic.edu

Education:

The Ohio State University Ph.D. (Pharmacognosy) 1961-1965
University of Pittsburgh M.S. (Pharmacognosy) 1959-1961
University of Pittsburgh B.S. (Pharmacy) 1955-1959

Research Interests:

Major research interests are in the areas of collaborative drug discovery from higher plants, which include the acquisition of source materials through good agriculture and field collection practice (GACP) and the bioassay-directed phytochemical isolation and biology of potentially active antitumor, cancer chemopreventive, anti-malarial, and anti-TB agents; of qualitative and quantitative QA/QC of natural products and herbal medicine; of standardization of botanical dietary supplements and traditional herbal medicines; of basic and translational evidence-based traditional herbal medicine; and of monographing medicinal plants; of development of pharmacopoeia and standards for medicinal plants

Professional Organizations:

American Society of Pharmacognosy (Honorary Member, 2004-present)

Honors:

Group

American Society of Pharmacognosy (Vice President 1977-1978; President 1978-1979); Society for Economic Botany (Treasurer, 1975-1977, Vice President 1980-1981, President 1981-1982), Adjunct Professor, RMIT University, Melbourne, Australia (2006-present); Honorary Visiting Research Fellow, Institute of Science and Technology, The Chinese University of Hong Kong (1977); Honorary Professor, Hong Kong Baptist University, Hong Kong, SAR, China; Visiting Professor, Guangzhou University of Traditional Chinese Medicine, Guangzhou, PRC (1993-2001); External examiner, School of Chinese Medicine, Chinese Univ. Hong Kong (2005- present); recipient of the Jack L. Beal Post Baccalaureate Alumnae Award, The Ohio State University 1997; the 2008 Natural Products Association, Burton Kallman Scientific Award; member of the WHO Expert Panel on Traditional Medicine (1997-present); member, International Advisory Board on Hong Kong Regulatory Standards for Chinese Medicinal Herbs (HKCMMS), Hong Kong, SAR, China (2001 - Present); member, Advisory Board of the Tang Center for Herbal Medicine Research, University of Chicago, 2003-present; member, Complementary and Alternative Medicine for Urological Symptoms Data and Safety Monitoring Board (NIH) (2003-presaent; Member, Expert Panel to Review the ODS Analytical Methods and Reference Materials (ODS, NIH). Served as consultant to the WHO/TRM, WHO Regional Office for the Western Pacific, WHO Eastern Mediterranean Regional Office, WHO South East Regional Office; and the World Bank, Department of Population, Health and Nutrition.

Editorial Duties:

Journal of Natural Products (Associate Editor, 1993-1998)
Member, Editorial Advisory Board of Oriental Pharmacy and Experimental Medicine (2002-2006)
Member, Editorial Advisory Board of American Journal of Chinse Medicine, (2003-present)
WHO Monograph on Selected Medicinal Plants, Vol. 1-4 (Co-writer, 1997-present)

Selected Publications (of more than 270):

  1. N.R. Farnsworth, H.H.S. Fong, R.N. Blomster and F.J. Draus. Studies on Vinca major (Apocynaceae), II. Phytochemical Investigation. J. Pharm. Sci., 1962, 51:217-224.
  2. Fong HHS, Beal JL, Cava MP. Alkaloids of Thalictum. Vll. Isolation of alkaloids from the roots of Thalictrum rochebrunianum. Lloydia, 1966, 29:94-100 (1966).
  3. Luyengi L, Che C-t, Bowen PE,Waller DP, Beecher CWW, Pezzuto JM, Fong HHS. Linusitamarin, a new phenylpropanoid glucoside from Linum usitatissimum L., Journal of Natural Products. 1993, 56:2012-2015.
  4. Breemen RB van, Huang C-R, Lu Z-Z, Rimando A, Fong HHS, Fitzloff JF. Electrospray liquid chromatography/mass spectrometry of ginsenosides. Anal. Chem. 1995, 67: 3985-3989.
  5. Sun H-d, Wang Z-y, Lin Z-w, Qiu S-x, Lin L-z, Pengsuparp T, Pezzuto JM, Fong HHS, Cordell GA, Farnsworth NR. Nigranoic acid, a triterpenoid inhibiting HIV-1 reverse transcriptase from Schisandra sphaerabdra. Journal of Natural Products 1996, 59: 525-527.
  6. Jiang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher, CWW, Fong HHS, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science, 1997, 275, :218-220.
  7. Qiu S-x, Sun H-d, Lobkovsky E, Chai H, ClardyJ, Farnsworth NR, Pezzuto JM, Fong HHS.Megathyrin B a cytotoxic diterpene from Isodon megathyrsus. Planta Medica, 1998, 64:1-4.
  8. Fong HHS, Kosmeder JW, Farnsworth NR, Soejarto DD, Kinghorn AD, J.M. Pezzuto. Edible plants as sources of cancer chemopreventive agents. Proc. Intern. Forum Trad. Med., Toyama, Oct. 16-17, 1999.
  9. Li W-k, Gu C-g, Zhang H-j, Awang DVC, Fitzloff JF, Fong HHS, van Breemen RB. Use of high performance liquid chromatography-tandem mass spectrometrytodistinguish Panax ginseng C.A. Meyer (Asian ginseng) and Panax quinquefolius L. (North American ginseng). Analytical Chemistry , 2000, 72: 5417-5422.
  10. Liu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat, K, Booth N, Constantinou AI, Pezzuto JM, Fong HHS, Farnsworth NR, Bolton JL. Evaluation of estrogrnic activity of plant extracts for the potential treatment of menopausal symptoms. Journal of Agricultural Food Chemistry, 2001, 49:2472-2479.
  11. Zhang H-J, Tan GT, Vu DH, Nguyen VH, Nguyen MC, Do TH, Soejarto DD, Pezzuto JM, Fong HHS. Natural anti-HIV agents. Part II. Litseaverticillol A, a prototypic litseane sesquiterpene from Litsea verticillata. Tetrahedron Letters 2001, 42:8587-8591.
  12. Li W, Fong HHS, Singletary KW, Fitzloff JF. Determination of catechins in commercial gape seed extract. Journal of Liquid Chromatography & Related Technology, 2002, 25:397-407.
  13. Chen S-N, Li W, Fabricant DS, Santiarsiero BD, Mesecar A, Fitzloff JF, Fong HHS, Farnsworth NR. Isolation, structure elucidation and absolute configuration of 26-deoxyactein from Cimicifuga racemosa and clarification of nomenclature associated with 27-deoxyactein. Journal of Natural Products, 2002, 65:601-605
  14. Zhang H-J, Tamez PA, Aydogmus Z, Ghee Teng Tan, Saikawa Y, Hashimoto K, Nakata M, Nguyen Van Hung, Le Thi Xuan, Nguyen Manh Cuong, Soejarto DD, Pezzuto JM, Fong HHS. Antimalarial Agents from Plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva. Planta Medica, 2002, 68:1088-1091.
  15. Li S-H, Zhang H-j, Niu X-M, Yao P, Yao P, Sun H-D, Fong HHS. Novel taxoids from the Chinese yew, Taxus yunnanensis. Tetrahedron, 2003, 59:37-45.
  16. Chadwick LR, Nikolic D, Burdette JE, Overk CR, Bolton JL, van Breemen RB, Fröhlich R, Fong HHS, Farnsworth NR, Pauli GF. Estrogens and Congeners from Spent Hops (Humulus lupulus L.) Journal of Natural Products, 2004, 67:2024-2032.
  17. Ma CY, Case RJ, Wang YH, Zhang H-J, Tan GT, Nguyen Van Hung, Nguyen Manh Cuong, Franzblau SG, Soejarto DD, Fong HHS, Pauli GF. Antituberculosis constituents from Micromelum hirsutum. Planta medica. 2005, 71:261-267.
  18. Zhang H-J, Ma C, Nguyen Van Hung, Nguyen Manh Cuong, Tan G, Santarsiero BD, Mesecar A, Soejarto D, Pezzuto JM, Fong HHS, Miliusanes, a novel class of cytotoxic agents from Miliusa sinensis, Journal of Medicinal Chemistry, 2006, 49:693-708.
  19. Xie J-T, Chang W-T, Wang C-Z, Mehendale SR, Li J, Ambihaipahar R, Ambihaipahar U, Fong HHS, Yuan C-S. Curry leaf (Murraya koenigii Spreng.) reduces blood cholesterol and glucose levels in ob/ob mice. The American Journal of Chinese Medicine, 2006, 34: 279–284.
  20. He Z-D, Ma C-Y, Zhang H-J, Sydara K, Tan GT, Tamez P, Southavong B, Bouamanivong S, D. DD, Pezzuto JM, Fong HHS. Rourinoside and rouremin, new antimalarial constituents from Rourea minor. Phytochemistry. 2006, 67: 1378-1384.
  21. Deng S, Chen SN, Yao P, Nikolic D, van Breemen RB, Bolton JL, Fong HHS, Farnsworth NR, Pauli GF.Characterization of the serotonergic active principles of Angelica sinensis (Dang Gui) roots. Journal of Natural Products, 2006, 69:536-541.
  22. van Breemen RB, Fong HHS, Farnsworth NR. The role of quality assurance and standardization in the safety of botanical dietary supplements. Chemical Research in Toxicology. 2007, 20:577-585.
  23. Jutiviboonsuk A, Zhang H-J, Kondratyuk TP, Herunsalee A, Chaukul W, Pezzuto JM, Fong HS, Bunyapraphatsara N. Isolation and characterization of cancer chemopreventive compounds from Barringtonia maunwongyathiae. Pharmaceutical Biology. 2007, 45: 185-194.
  24. Chan S S-K, Zhao M, Lao L, Fong HHS, Che C-T. Magnolol and honoliol account for the antispasmodic effect of Magnolia officinalis in isolated guinea pig ileum. Planta Medica. 2008 74: 381-384.
  25. Zhang R-X, Fan AY, Zhou A-N, Moudgil KD, Ma Z-Z, Lee D Y-W, Fong HHS, Berman BM, Lixing Lao. Extract of the Chinese herbal formula Huo Luo Xiao Ling Dan inhibited adjuvant arthritis in rats. Journal of Ethnopharmacology, 2009,121:366–371.
  26. Rajaiaha R, Lee D Y-W, Lao L, Fong HHS, Berman BM, Moudgil KD. Huo-Luo-Xiao-Ling Dan modulates antigen-directed immune response in adjuvant-induced inflammation. Journal of Ethnopharmacology, 2009, 123:40–44.

Selected book chapters

  1. Bingel AS, Fong HHS. Potential Fertility Regulating Agents from plants. In: Economic and Medicinal Plant Research. Vol. 2. Wagner H, Hikino H, Farnsworth NR (eds). London, Academic Press, 1988.
  2. Chadwick L, Fong HHS. Herb quality assurance and standardization in herb-drug interaction evaluation and documentation. In: Lam YWF, Huang S-M, Hall SD (eds). Herbal Supplement – Drug Interactions. New York, Taylor & Francis, 2006.
  3. Fong HHS, Pauli GF, Bolton JL, van Breemen RB, Banuvar S, Shulman L, Geller SE, Farnsworth NR. Evidence-based herbal medicine: Challenges in efficacy and safety assessments. In: Leung P-C, Fong H, Xue CC (eds). Current Review of Chinese Medicine, Annals of Traditional Chinese Medicine, Vol. 2. World Scientific, Singapore, 2006.
  4. Soejarto DD, Gyllenhaal C, Tarzikan-Sorensen JA, Fong HHS, Xuan LT, Binh LT, Hiep NT, Hung NV, Vu BM, Bich TQ, SouthavongB, Sydara K, Pezzuto JM. Bioprospecting arrangement:Experience between the North and the South. In: Krattiger A, RT Mahoney, L Nelsen, JA Thomson, AB Bennett, K Satyanarayana, GD Graff, C Fernandez and SP Kowalski (eds.). Intellectual Property Management in Health and Agricultural Innovation: A Handbook of Best Practices . MIHR: Oxford, U.K., and PIPRA: Davis.

Selected books edited

  1. Leung P-C, Fong H, Xue CC. Eds. Annals of Traditional Chinese Medicine, Vol. 2. Current Review of
    Chinese Medicine. World Scientific, Singapore, 2006.
  2. Leung P-C, Fong H. Eds. Annals of Traditional Chinese Medicine, Vol. 3. Alternative Treatment for
    Cancer. World Scientific, Singapore, 2007.
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