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Scott G. Franzblau, Ph.D. Scott Franzblau

Professor
Department of Medicinal Chemistry and Pharmacognosy
Director, Institute for Tuberculosis Research

University of Illinois at Chicago
College of Pharmacy
833 S. Wood Street (M/C 964)
Chicago, IL 60612-7231

Office: 412A PHARM
Office Phone: 312-355-1715
Fax Number: 312-355-2693
E-mail address: sgf@uic.edu
Link: http://itr.pharm.uic.edu

Research Interests:

The ITR is pursuing several strategies for discovery of new anti-TB agents. This includes large scale screening of both natural and synthetic compounds for those that demonstrate specificity of activity (i.e. inhibit the TB bacillus but not mammalian cells). Lead compounds are then optimized by semi-synthesis. In addition we are attempting to optimize the anti-TB activity of classes of antibiotics used for other infections but that have not been clinically active in tuberculosis. Activity of all lead compounds are assessed in macrophage and mouse models of TB. Ultimately clinical trials will be conducted with collaborators in TB-endemic regions.

Select Publications:

  1. Ma, Y., Stern, R.J., Scherman, M.S., Vissa, V.D., Yan, W., Jones, V.C., Zhang, F., Franzblau, S.G., Lewis, W.H. and McNeil, M.R. 2001. Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose. Antimicrobial Agents and Chemotherapy 45:1407-1416.
  2. Rugutt, J.K, Fronczek, F.R., Franzblau, S.G. and Warner, I.M. 2001. Dihydroparthenolide diol, a novel sesquiterpene lactone. Acta Crystallographica E57: o323-o325.
  3. Wächter, G.A., Valcic, S., Franzblau, S.G., Suarez, E., and Timmermann, B.N. 2001. Antitubercular triterpenoids from Lippia turbinate. Journal of Natural Products 64:37-41.
  4. Caldwell, C.G, Franzblau, S.G., Suarez, E. and Timmermann, B.N. Oleanene triterpenoids from Junellia tridens. 2000. Journal of Natural Products 63:1611-1614.
  5. Konig, G.M., Wright, A.D. and Franzblau, S.G. 2000. Antimycobacterial activity assessment of a series of mainly marine derived natural products. Planta Medica 66:337-342.
  6. Acevedo, L., Martinez, E., Castaneda, P., Franzblau, S., Timmermann, Linares, E., Bye, R. and Mata, R. 2000. New phenylethanoids from Buddleja cordata subsp. Cordata. Planta Medica 66:257-261.
  7. Mangalindan, G.C., Talaue, M.T., Cruz, L.J., Franzblau, S.G., Adams, L.B., Richardson, A.D., Ireland, C.M. and Concepcion, G.P. 2000. Agelasine F from a Philippine Agelas sp. Sponge exhibits in vitro antituberculosis activity. Planta Medica 66:1-2.
  8. Rugutt, J. K., Henry, C. W., III, Franzblau, S. G. and Warner, I. M. 1999. NMR and molecular mechanics study of pyrethrins I and II. Journal of Agricultural and Food Chemistry 47:3402-3410.
  9. Timmermann, B.N., Wachter, G., Valcic, S., Hutchinson, B., Casler, C., Henzel, J., Ram, S., Currim, F., Manak, R., Franzblau, S., Maiese, W., Galanis, D., Suarez, E., Fortunato, R., Saavedra, E., Bye, R., Mata, R., and Montenegro, G. 1999. The Latin American ICBG: the first five years. Pharmaceutical Biology 37 (supplement):35-54.
  10. Wachter, G.A., Valcic, S., Flagg, M.L., Franzblau, S.G., Montenegro, G., Suarez, E. and Timmermann, B.N. Antitubercular activity of pentacyclic triterpenoids from plants of Argentina and Chile. Phytomedicine. 1999; 6(5);341-5.
  11. Cantrell, C. L.; Rajab, M. S.; Franzblau, S. G.; Fronczek, F. R., and Fischer, N. H. Antimycobacterial ergosterol-5,8-endoperoxide from Ajuga remota. Planta Med. 1999 Dec; 65(8):732-4.
  12. Adams, L. B.; Sinha, I.; Franzblau, S. G.; Krahenbuhl, J. L., and Mehta, R. T. Effective treatment of acute and chronic murine tuberculosis with liposome-encapsulated clofazimine. Antimicrob Agents Chemother. 1999 Jul; 43(7):1638-43.
  13. Cantrell, C. L.; Abate, L.; Fronczek, F. R.; Franzblau, S. G.; Quijano, L., and Fischer, N. H. Antimycobacterial eudesmanolides from Inula helenium and Rudbeckia subtomentosa. Planta Med. 1999 May; 65(4):351-5.
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