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Richard B. van BreemenRichard van Breemen

Professor of Medicinal Chemistry
Department of Medicinal Chemistry and Pharmacognosy

University of Illinois at Chicago
College of Pharmacy
833 S. Wood Street (M/C 781)
Chicago, IL 60612-7231

Office: 435B PHARM
Office Phone: 312-996-9353
Lab Phone: 312-413-1815
Fax Number: 312-996-7107
E-mail address: breemen@uic.edu
Lab homepage: http://www.uic.edu/labs/breemen

Education:

Johns Hopkins University Ph.D. 1985

Research Interests:

Cancer prevention by dietary antioxidants, and prostate cancer prevention by the carotenoid lycopene. Mass spectrometry-based pharmacological screening of natural products and combinatorial libraries for drug discovery, and high throughput screening to asses drug metabolism, toxicity and bioavailibility.

Recent Publications:

  1. Hua Y, Wainhaus SB, Yang Y, Shen L, Xiong Y, Xu X, Zhang F, Bolton JL, van Breemen RB. Comparison of Negative and Positive Ion Electrospray Tandem Mass Spectrometry for the Liquid Chromatography Tandem Mass Spectrometry Analysis of Oxidized Deoxynucleosides. J. Am. Soc. Mass Spectrom. 12, 80-87 (2001).
  2. Chang M, Shin YG, van Breemen RB, Blond SY, Bolton JL. Structural and Functional Consequences of Inactivation of Human Glutathione S-Transferase P1-1 Mediated by the Catechol Metabolite of Equine Estrogens, 4-Hydroxyequilenin. Biochemistry. 40, 4811-4820 (2001).
  3. Liu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL. Evaluation of Estrogenic Activity of Plant Extracts for the Potential Treatment of Menopausal Symptoms. J. Agric. Food Chem. 49, 2472-2479 (2001).
  4. Park EJ, Lee D, Shin YG, Lantvit DD, van Breemen RB, Kinghorn AD, Pezzuto JM. Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry. J Chromatogr B Biomed Sci Appl. 754, 327-32 (2001).
  5. van Lieshout M, West CE, Muhilal, Permaesih D, Wang Y, Xu X, van Breemen RB, Creemers AF, Verhoeven MA, Lugtenburg J. Bioefficacy of beta-carotene dissolved in oil studied in children in Indonesia. Am J Clin Nutr.73, 949-58 (2001).
  6. Mitchell DJ, Nikolic D, Rivera E, Sablin SO, Choi S, van Breemen RB, Singer TP, Silverman, RB. Spectrometric evidence for the flavin-1-phenylcyclopropylamine inactivator adduct with monoamine oxidase N. Biochemistry. 40, 5447-56 (2001).
  7. Nikolic D, van Breemen RB. DNA Oxidation induced by cyclooxygenase-2. Chem. Res. Toxicol. 14, 351-354 (2001).
  8. Zhang F, Yao D, Hua Y, van Breemen RB, Bolton JL. Synthesis and reactivity of the catechol metabolites from the equine estrogen, 8,9-dehydroestrone. Chem. Res. Toxicol. 14, 754-763 (2001).
  9. Mitchell DJ, Nikolic D, van Breemen RB, Silverman RB. Inactivation of monoamine oxidase B by 1-phenylcyclopropylamine:  Mass spectral evidence for the flavin adduct. Bioorg. Med. Chem. Lett. 11, 1757-1760 (2001).
  10. Mitchell DJ, Nikolic D, Jang MH, van Breemen RB, Hille R, Silverman  RB. Inactivation of C30A trimethylamine dehydrogenase by N-cyclopropyl-alpha-methylbenzylamine, 1-phenylcyclopropylamine, and phenylhydrazine. Biochemistry. 40, 8523-30 (2001).
  11. Wang Y, Chang WY, Prins GS, van Breemen RB. Simultaneous determination of all-trans, 9-cis, 13-cis retinoic acid and retinol in rat prostate using liquid chromatography-mass spectrometry. J. Mass Spectrom. 36, 882-888 (2001).
  12. Johnson BM, Bolton JL, van Breemen RB.  Screening Botanical Extracts for Quinoid Metabolites.  Chem. Res. Toxicol. 14, 1546-1551 (2001).
  13. Garbis SD, Melse-Boonstra A, West CE, van Breemen RB.  Determination of Folates in Human Plasma Using Hydrophilic Interaction Chromatography-Tandem Mass Spectrometry.  Anal. Chem. 73, 5358-5364 (2001).
  14. Zhang F, Swanson SM, van Breemen RB, Liu X, Yang Y, Gu C, Bolton JL.  Equine Estrogen Metabolite 4-Hydroxyequilenin Induces DNA Damage in the Rat Mammary Tissues: Formation of Single-Strand Breaks, Apurinic Sites, Stable Adducts, and Oxidized Bases. Chem. Res. Toxicol. 14, 1654-9 (2001).
  15. Yao D, Zhang F, Yu L, Yang Y, van Breemen RB, Bolton JL.  Synthesis and Reactivity of Potential Toxic Metabolites of Tamoxifen Analogues: Droloxifene and Toremifene o-Quinones.  Chem. Res. Toxicol. 14, 1643-53 (2001).
  16. Chen L, Stacewicz-Sapuntzakis M, Duncan C, Sharifi R, Ghosh L, van Breemen R, Ashton D, Bowen PE.  Oxidative DNA Damage in Prostate Cancer Patients Consuming Tomato Sauce-Based Entrees as a Whole-Food Intervention. J. Natl. Cancer Inst. 93, 1872-9 (2001).
  17. Shin YG and van Breemen RB.  Analysis and Screening of Combinatorial Libraries using Mass Spectrometry.  Biopharmaceutics and Drug Disposition.  22, 353-72 (2001).
  18. Constantinou AI, Lantvit D, Hawthorne M, Xu XY, van Breemen RB, Pezzuto JM.  Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats.  Nutr. Cancer Int. J. 41, 75-81 (2001).
  19. Burdette JE, Liu J, Lantvit D, Lim E, Booth N, Bhat KPL, Hedayat S, van Breemen RB, Constantinou AI, Pezzuto JM, Farnsworth NR, Bolton JL.  Trifolium pratense (Red Clover) Exhibits Estrogenic Effects In Vivo in Ovariectomized Sprague-Dawley Rats. J. Nutr. 132, 27-30 (2002).
  20. Shin YG, Bolton JL, van Breemen RB. Screening drugs for metabolic stability using pulsed ultrafiltration mass spectrometry. Combin. Chem. & High Through.Screen.5, 59-64 (2002).
  21. Wang Y, Catana F, Yang Y, Roderick R, van Breemen RB.  An LC-MS method for analyzing total resveratrol in grape juice, cranberry juice, and in wine. J Agric Food Chem. 50, 431-5 (2002).
  22. van Breemen RB, Xu X, Viana MA, Chen L, Stacewicz-Sapuntzakis M, Duncan C, Bowen PE, and Sharifi R. Liquid chromatography-mass spectrometry of cis- and all-trans-lycopene in human serum and prostate tissue after dietary supplementation with tomato sauce. J. Agric. Food Chem. 50, 2214-9 (2002).
  23. Liu X, Yao J, Pisha E, Yang Y, Hua Y, van Breemen RB, and Bolton JL.  Oxidative DNA Damage Induced by Equine Estrogen Metabolites: Role of Estrogen Receptor a.  Chem. Res. Toxicol. 15, 512-9 (2002).
  24. Constantinou AI, Lucas LM, Lantvit D, Hawthorne M, Xu X, Nho CW, Jeffery EH, Christov K, van Breemen RB, Pezzuto JM.  Soy protein isolate prevents chemically induced rat mammary tumors.  Pharmaceutical Biology.  40, 24-34 (2002). 

van Breemen lab photo
van Breemen lab photo

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